ABSTRACT
The immunocompromised disease is a health condition characterized by weakened immunity due to comorbidities (like cancer and HIV), medical procedures (including surgeries, bone marrow, organ, and stem cell transplantation), and treatments resulting in susceptibility, the severity of disease or recurrent infections. An immunocompromised individual is at increased risk of getting infected and progressing of disease present. In the presence of a global pandemic amidst several communicable infections, there is an increase in so many burdens related to health and wellness;a lot of individuals have become more concerned about their health, nutrient intake, and wellbeing. A healthy functioning immune system is very essential for body function and the need for immune-modulatory micronutrients, for instance, zinc, vitamin A Vitamin D emerges either through supplementation or from a natural source (which is optimum) for a healthy population. The immune systems are comprised of important cells (innate and adaptive immune response) responsible for performing defence and regulatory functions in the body. This review focuses on the implication of micronutrients in the regulation and maintenance of the immune system for the proper functioning and prevention against disease development, progression, or severity of these diseases.